According to the 2016 AHA Scientific Statement:
“Recommendations for Management of Clinically Significant Drug-Drug Interactions With Statins and Select Agents Used in Patients With Cardiovascular Disease” p e470 & e 473:
Combination of lovastatin or simvastatin with which of the following drugs “is
potentially harmful” and the clinical recommendation is to “Avoid combination”?
(In the other choices below, the doses of lovastatin and simvastatin are recommended to be limited when used in combination with the non-statin drug).
b) amlodipine, diltiazem or verapamil
c) tacrolimus or conivaptan